Novexatin Antifungal peptides (AFPs) are a remarkable class of molecules that nature has evolved to combat fungal infections. These peptides exhibit broad antimicrobial activity, making them powerful candidates for therapeutic applications and also for preserving food productsPeptides from pinto bean and red beanwith sequence homology to cowpea 10-kDa protein precursor exhibit antifungal, mitogenic, and HIV-1 reverse transcriptase- .... Found across a diverse range of taxa, from bacteria and plants to insects and mammals, AFPs represent a crucial component of innate immunity and a promising frontier in the development of new antifungal strategies. Their ability to inhibit or kill pathogenic fungi through various mechanisms, often by targeting the fungal cell membrane, underscores their therapeutic potential against a wide spectrum of fungal pathogens, including those resistant to conventional treatments.
Antifungal peptides are not confined to a single biological kingdom. They are integral to the defense mechanisms of plants, protecting them against a wide range of fungal pathogens. Mammals also utilize AFPs, with histatins, cathelicidins, and defensins being major groups found in mammalian systems. Insects, too, possess AFPs as part of their immune response.Antifungal agents - PubMed This widespread presence highlights their evolutionary significance.Potent in vitro and in vivo antifungal activity of a small ...
The mechanisms by which AFPs exert their antifungal effects are varied and often involve direct interaction with the fungal cell. Many AFPs are known to disrupt the fungal cell membrane, leading to cell death.作者：LP Menzel·2017·被引用次数：43—By in vitro screening of small molecule mimics of naturally occurring host defensepeptides(HDP), we have identified several activeantifungal... This can manifest as pore formation, membrane permeabilization, or disruption of membrane integrity, which ultimately inhibits mycelial growth or affects spore germination.Antifungal Peptides: Novel Therapeutic Compounds ... Some AFPs may also have intracellular targets, interacting with nucleic acids or other cellular components to halt fungal progression. The development of synthetic peptide mimics that can replicate these natural defense strategies is also an active area of research, offering new avenues for drug discovery.
The efficacy of antifungal peptides against pathogenic fungi, including challenging species like *Candida albicans*, has positioned them as promising candidates for novel antifungal therapies作者：CG Freitas·2023·被引用次数：27—Antifungal peptides(AFPs) have gained considerable attention as potential candidates for combating Candida spp. infections.. Their potential to overcome antifungal-resistant infections is particularly significant, given the growing threat of drug-resistant fungal strains. Research into peptide-based antifungal therapies is exploring their in vitro and in vivo activities, aiming to harness their biological repercussions on fungal cells for clinical benefit.作者：CG Freitas·2023·被引用次数：27—Antifungal peptides(AFPs) have gained considerable attention as potential candidates for combating Candida spp. infections.
However, challenges remain in translating this potential into widespread clinical use.Candida albicans and Antifungal Peptides - Springer Link While some approved antifungal agents, such as those in the echinocandin family (micafungin, caspofungin, and anidulafungin), share some characteristics with peptides, direct peptide-based drugs are still largely in development.作者：CG Freitas·2023·被引用次数：27—Antifungal peptides(AFPs) have gained considerable attention as potential candidates for combating Candida spp. infections. Optimizing the therapeutic efficacy of these peptides, understanding their structure-function relationships, and ensuring their safety and stability are critical areas of ongoing investigation. Furthermore, the development of dendritic antifungal peptides and modifications to existing structures are being explored to enhance their potency and broaden their application.
The utility of antifungal peptides extends beyond human and animal health.作者：R Cheng·2021·被引用次数：27—The results indicate thatMAF-1A disrupts the cell membrane of C. albicansand enters the cell where it binds and interacts with nucleic acids. Their ability to inhibit fungal growth and spoilage makes them attractive as natural antimicrobial agents for food preservation. For instance, certain AFPs can increase the shelf life of fermented milk products by combating contamination from filamentous fungi and yeast. This application aligns with the growing consumer demand for natural and minimally processed food products.作者：J Song·2024·被引用次数：9—Antifungal peptides (AFPs)have the potential to treat antifungal-resistant infections; however, their structure–function relationship remains unknown, ... Research into modifying antifungal peptides for use as safe food preservatives is actively being pursued, offering a sustainable alternative to traditional chemical preservatives作者：A Matejuk·2010·被引用次数：206—To date, the only approved antifungal peptides are in theechinocandin family(micafungin, caspofungin, and anidulafungin); precursors of these ....
The study of antifungal peptides is a dynamic and rapidly evolving field. Bioinformatics approaches are playing an increasingly vital role in the discovery of new AFPs, accelerating the identification of novel candidates from vast biological datasets. As our understanding of their diverse origins, mechanisms of action, and therapeutic potential deepens, antifungal peptides are poised to become increasingly important tools in combating fungal infections across medicine, agriculture, and the food industry.作者：E Simons·2025—We investigate the use ofantimicrobial peptides (AMPs) as a new source for food preservatives to combat filamentous fungi and yeast contamination. Continued research into their biosynthesis, production, and optimization will be key to unlocking their full potential.
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