Peptide YY hormonefunction Peptide YY (PYY) is a crucial gut hormone that plays a significant role in regulating appetite and influencing overall energy homeostasis作者：RL Batterham·2003·被引用次数：2178—The gut hormone fragment peptide YY3–36 (PYY)reduces appetite and food intakewhen infused into subjects of normal weight. In common with the adipocyte .... Released primarily in response to food intake, PYY acts as a satiety signal, helping to curb hunger and limit food consumption. This 36-amino acid peptide, belonging to the pancreatic polypeptide family, is secreted by L-cells located in the lining of the ileum and colon. Its multifaceted roles extend beyond appetite control, impacting gastrointestinal motility, secretion, and even glucose metabolism, making it a subject of considerable scientific interest作者：R Batterham·2008—Exogenous administration of the gut hormone peptide YY3-36 (PYY3-36)reduces food intake in obese humans and rodents. New lines of evidence support a role ....
The primary and most well-known function of Peptide YY is its potent anorectic effect. When nutrients, particularly fats and carbohydrates, come into contact with the intestinal lining, they stimulate the release of PYY into the bloodstream. This release is often proportional to the energy content of the mealPeptide YY: obesity's cause and cure?. Once circulating, PYY travels to the brain, where it interacts with specific neuropeptide Y receptors, particularly Y2 receptors in the hypothalamus. This interaction signals satiety, leading to a reduced desire to eat and a feeling of fullness. Studies have consistently shown that exogenous administration of PYY, especially the PYY3-36 fragment, can significantly reduce food intake and promote weight loss in both lean and obese individuals, highlighting its potential as a therapeutic target for obesity management.
Peptide YY's influence extends to various aspects of gastrointestinal function. It acts as a physiological regulator of intestinal absorption and plays a role in motility. Specifically, PYY has been observed to cause intestinal constriction, which can inhibit motility in the jejunum and colon. Furthermore, it can suppress pancreatic secretion, including bicarbonate and protein, which are essential for digestion.Peptide YY: more than just an appetite regulator | Diabetologia These actions contribute to the overall regulation of nutrient processing and absorption within the digestive tract, ensuring efficient nutrient uptake after a meal.What is Peptide YY (PYY)?
Emerging research indicates that Peptide YY's influence reaches into metabolic regulation, particularly concerning glucose metabolism and its implications for conditions like Type 2 Diabetes. PYY is considered a pleiotropic gut hormone involved in modulating glucose metabolism, encompassing both insulin and glucagon secretion. While its precise role is still being elucidated, PYY may contribute to maintaining glucose balance.Peptide YY Is a Regulator of Energy Homeostasis in Obese ... Furthermore, PYY levels have been found to be reduced in individuals with obesity, suggesting a potential link between impaired PYY signaling and the development or maintenance of excess weight. Understanding this connection could offer new avenues for addressing metabolic disordersPYYis a short-term appetite regulator of the neuropeptide Y family, released in proportion to meal energy content and shown to reduce food intake in rodents ....
Interestingly, recent findings suggest that Peptide YY may also play a role in maintaining the health of the gut microbiome. While the exact mechanisms are still under investigation, this emerging role underscores the complex and interconnected functions of this versatile gut hormone.Peptide YY: more than just an appetite regulator | Diabetologia
Peptide YY is a vital gut hormone that orchestrates a complex interplay of physiological responses, primarily centered around appetite regulation and satiety. Its release in response to nutrient intake signals fullness to the brain, helping to control food consumption. Beyond this, PYY influences gastrointestinal motility and secretion, and is increasingly recognized for its potential roles in metabolic health and gut microbiome balance. The consistent findings regarding PYY's ability to reduce appetite and food intake, particularly in obese individuals, position it as a promising candidate for the development of novel therapeutic strategies aimed at combating obesity and related metabolic disorders. Continued research into the intricate mechanisms and broader functions of Peptide YY promises to unlock further insights into human physiology and health作者：R Batterham·2008—Exogenous administration of the gut hormone peptide YY3-36 (PYY3-36)reduces food intake in obese humans and rodents. New lines of evidence support a role ....
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