Myelin oligodendrocyte glycoprotein The MOG peptide, specifically the MOG (35-55) fragment, is a crucial tool in neuroscience research, primarily used to induce experimental autoimmune encephalomyelitis (EAE) in animal models. This peptide is derived from myelin oligodendrocyte glycoprotein (MOG), a protein vital for nerve myelination in the central nervous system (CNS). Researchers utilize the MOG (35-55) peptide to investigate the mechanisms behind demyelinating diseases like multiple sclerosis (MS) and MOG antibody disease (MOGAD). The induction of EAE by this peptide allows for the study of T and B cell responses and the resulting neurological pathology, including plaque-like demyelination.
Myelin oligodendrocyte glycoprotein (MOG) is a key component of the myelin sheath in the CNSMyelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system.MOG(35-55) .... When fragmented into specific sequences, such as the MOG (35-55) peptide, it can act as an antigen. In animal models, inoculation with MOG peptides, particularly the highly encephalitogenic MOG (35-55) peptide, triggers an immune response that mimics human autoimmune neurological disorders. This response involves the activation of CD4+ and CD8+ T cells, leading to inflammation and demyelination within the CNS, closely resembling the pathological hallmarks of conditions like multiple sclerosis.
The MOG (35-55) peptide is widely recognized for its ability to induce experimental autoimmune encephalomyelitis (EAE) in various mouse strains, such as C57BL/6. EAE is a well-established animal model for studying demyelinating diseases.Mog myelin oligodendrocyte glycoprotein [ (house mouse)] The administration of this peptide fragment can lead to a relapsing-remitting neurological disease characterized by significant demyelination, mirroring the clinical manifestations observed in multiple sclerosis. Researchers use these models to explore therapeutic strategies and understand the pathogenesis of these conditions.
The study of MOG peptides is intrinsically linked to understanding autoimmune diseases affecting the nervous system. The MOG protein itself is a target in autoimmune conditions such as MOG antibody disease (MOGAD).Myelin Oligodendrocyte Glycoprotein (MOG) peptide By using specific MOG peptide fragments like MOG (35-55), scientists can precisely investigate the immune response against MOG.Human (MOG 1-125) and (MOG-35-55) Myelin ... This allows for detailed analysis of how T and B cells recognize and attack myelin components, providing critical insights into the development of autoimmune encephalomyelitis and related neurological disorders.MOG Peptides, Myelin Oligodendrocyte Glycoprotein
While MOG (35-55) is the most commonly cited peptide for inducing EAE, other MOG peptide fragments, such as MOG (91-108), also play roles in immune signaling pathways within the CNS. Researchers may use different MOG peptide sequences to probe specific epitopes or to create varied models of neurological disease. The purity and formulation of these peptides, often supplied as TFA or acetate salts, are crucial for reproducible experimental results. These MOG peptides are invaluable tools for advancing research into neuroinflammation and autoimmune conditionsAmyloid-like Behavior of Site-Specifically Citrullinated Myelin ....
In conclusion, MOG peptides, particularly the MOG (35-55) fragment, are instrumental in experimental models of autoimmune neurological diseases. Their ability to induce EAE provides a critical platform for understanding the immune mechanisms underlying conditions like multiple sclerosis and MOGAD, driving progress in the search for effective treatmentsMyelin Oligodendrocyte Glycoprotein (MOG)Peptide. Species: Human. Source: Synthetic. Order product ABIN5685318..
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