Mog3555sequence The MOG 35-55 peptide is a crucial tool in neuroscience research, particularly for understanding and modeling autoimmune demyelinating diseases like multiple sclerosis (MS). This specific peptide fragment, derived from the Myelin Oligodendrocyte Glycoprotein (MOG), is widely used to induce experimental autoimmune encephalomyelitis (EAE) in animal models. EAE closely mimics the pathological hallmarks of MS, including inflammation and demyelination in the central nervous system, making MOG (35-55) an invaluable reagent for studying disease mechanisms and testing potential therapeutic interventions.
Myelin oligodendrocyte glycoprotein (MOG) is a protein found on the surface of myelin sheaths in the central nervous system.MOG (35-55) TFA (Myelin Oligodendrocyte Glycoprotein ... In certain autoimmune conditions, the immune system mistakenly targets MOG, leading to the destruction of myelin. The MOG 35-55 peptide fragment specifically represents an immunodominant epitope within the MOG protein. When administered to susceptible animal models, such as mice and rats, this peptide elicits a robust immune response characterized by T cell activation and the production of autoantibodies against MOGMyelin Oligodendrocyte Glycoprotein Peptide Fragment 35 .... This immune assault results in significant demyelination and neurological dysfunction, closely mirroring the relapsing-remitting and chronic progressive forms of multiple sclerosis observed in humansBackground.MOG(35-55) is a truncatedpeptidederived from the human Myelin Oligodendrocyte Glycoprotein (MOG).MOG, a member of the immunoglobulin superfamily .... Researchers utilize this induced EAE model to investigate the intricate interplay between the immune system and the central nervous system, seeking to identify key cellular and molecular pathways that drive disease pathogenesis.
The primary utility of the MOG 35-55 peptide lies in its ability to reliably induce a predictable EAE model. This allows scientists to:
* Investigate Autoimmune Mechanisms: By studying the immune response triggered by MOG (35-55), researchers gain insights into the specific T cell epitopes that are recognized as foreign, the signaling pathways involved in inflammation, and the mechanisms by which myelin is damagedHow to dissolve and store Myelin Oligodendrocyte ....
* Evaluate Therapeutic Efficacy: Pre-clinical studies often employ the MOG (35-55) induced EAE model to test the effectiveness of novel drugs and therapies designed to treat MS. This includes evaluating agents that might suppress the immune response, protect myelin, or promote remyelination.
* Study Disease Progression and Pathology: The peptide allows for the controlled induction of demyelinating lesions, enabling detailed examination of the pathological changes that occur during the disease course, from acute inflammation to chronic neurodegeneration2025年11月20日—Influence of diet andMOG 35-55 peptidepreparation on severity ... CD4-Positive T-Cell Responses to MOG Peptides in MOG Antibody-Associated ....
* Explore Genetic and Environmental Factors: Researchers can use the MOG (35-55) model to investigate how genetic predispositions or environmental factors might influence disease susceptibility and severity.Buy Mog 35 55 Peptide for Sale Online
High-purity MOG 35-55 peptide is essential for reproducible research outcomes. Suppliers typically offer the peptide in various forms, often as a TFA (trifluoroacetate) salt, and specify purity levels, usually determined by HPLC (High-Performance Liquid Chromatography). The sequence of the MOG 35-55 peptide, often represented as MEVGWYRPPFSRVVHLYRNGK, is critical for its immunogenic properties.MOG(35-55), Human_UA080263_斯达特公司官网 Researchers must ensure that the peptide is sourced from reputable vendors to guarantee its quality, integrity, and ability to consistently induce EAE. Storage conditions, typically at -20°C, are also important for maintaining peptide stability.
While MOG is a significant target in autoimmune CNS diseases, the 35-55 fragment is particularly notable for its encephalitogenic properties. Other fragments of MOG may also be immunogenic or play roles in immune responses, but the 35-55 sequence is the most widely recognized and utilized for inducing EAE models that closely replicate the pathology of multiple sclerosis. This specificity makes it a valuable and distinct tool in the field of neuroimmunologyMyelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic ....
Join the newsletter to receive news, updates, new products and freebies in your inbox.