PTHrPcancer Parathyroid hormone-related peptide (PTHrP) is a protein that, while structurally similar to parathyroid hormone (PTH), plays a distinct and increasingly recognized role in the context of lung cancer.Cell cycle actions of parathyroid hormone-related protein in ... Research indicates that PTHrP is not merely an incidental finding but can actively influence tumor growth, progression, and even survivalSex-Specific Survival Advantage with Parathyroid Hormone .... Its presence and activity in lung cancer cells, particularly in non-small cell lung carcinomas (NSCLC) and squamous cell lung cancer, are subjects of intense study, offering potential insights into disease mechanisms and prognostic indicators.
The involvement of PTHrP in lung cancer is multifaceted, impacting cellular processes in ways that can both promote and, in some contexts, inhibit tumor development作者：G Almadori·2022·被引用次数：5—Parathyroid hormone-related peptide(PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies .... Early research established that PTHrP could be produced by lung cancer cells, and subsequent studies have delved deeper into its specific actions.作者：A Kaur·2022—It is most commonly associated withlung cancer, with a reported incidence up to 12.5% in those at advanced stages. While elevatedPTHrPlevels have been ... For instance, certain fragments of PTHrP, such as PTHrP 1–34 and PTHrP 140–173, have been shown to protect lung cancer cells from apoptosis, or programmed cell death, thereby enhancing cell survival. This anti-apoptotic effect is crucial for tumor persistence and growth.
Furthermore, PTHrP has been implicated in regulating the growth of human lung cancer cells. While some studies suggest it can inhibit growth by slowing cell cycle progression into the S phase, other findings point to its role in carcinoma progression and metastasisParathyroid hormone-related protein purified from a human .... The protein's ability to influence cell-to-cell interactions, including interactions with osteoclast cells, further highlights its potential to mediate tumor spread and bone metastasis, a common complication of advanced lung cancer.
The abnormal expression of PTHrP is a common feature in a substantial majority of lung cancers, making it a potential biomarker. Elevated PTHrP levels in primary human lung tumors have been correlated with an increased risk of metastasis. In some cases, PTHrP expression is considered a poor prognostic sign, associated with more advanced tumors. This is particularly noted in squamous cell carcinomas, which are frequently PTHrP-producing. However, research also shows elevated PTHrP in adenocarcinomas, suggesting its role is not limited to a single histological subtype. The presence of PTHrP can also be linked to paraneoplastic syndromes, such as humoral hypercalcemia of malignancy (HHM), where the tumor produces substances that alter calcium metabolism.Parathyroid Hormone-Related Peptide - Medscape Reference While not all tumors expressing PTHrP secrete it in amounts sufficient to affect calcium levels, its association with HHM is a significant clinical observation.
It is essential to differentiate PTHrP from parathyroid hormone (PTH). While they share structural similarities and can interact with the same receptor (PTH1R), their origins and primary functions differPTHrP (parathyroid hormone-related protein)is abnormally expressed in a substantial majority of lung cancers, especially non-small cell lung cancers, and plays .... PTH is primarily produced by the parathyroid glands and is the main regulator of calcium and phosphate levels in the blood.作者：G Monego·2010·被引用次数：20—PTHrP has long been known as a key player in cancer bone metastasis.PTHrP levels in primary human lung tumors are correlated with the risk of metastasisand ... PTHrP, on the other hand, is produced by a variety of normal tissues and is aberrantly expressed in many cancers, including lung cancer. Its role in normal physiology is less understood but is thought to involve functions like skeletal development and cell growth regulation. In the context of cancer, PTHrP's production by tumor cells leads to various effects, including the potential for hypercalcemia and influence on tumor microenvironment.
Understanding the complex role of PTHrP in lung cancer opens avenues for potential therapeutic strategiesParathyroid hormone‐related peptide can regulate the growth .... Targeting PTHrP signaling pathways or its production could offer new ways to combat tumor growth and metastasis.Parathyroid Hormone-Related Protein (PTHrP) Research into the specific fragments of PTHrP and their varying effects, as well as the interaction of PTHrP with other signaling molecules, is ongoing. The development of diagnostic tests to measure PTHrP levels in serum or tissue could aid in early detection, prognosis, and monitoring treatment response. While the exact mechanisms are still being elucidated, the consistent association of PTHrP with lung cancer progression and patient outcomes underscores its importance in oncological research.
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